Simulation as a practical and versatile tool for sample size calculation
نویسنده
چکیده
Background The ethical significance of sample size is enshrined in principles of Good Clinical Practice and in quality standards for reporting trial results, yet sample size is often one of the most ill-considered aspects of a grant application. Researchers are also battling with an increasing complexity in study design. With some adaptive trial designs, for example, analytical solutions to sample size calculation problems may simply be unattainable. Monte Carlo simulation offers a general alternative.
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